Análisis de las propiedades biomecánicas y bioquímicas de dos tendones de rata con envejecimiento
DOI:
https://doi.org/10.24933/rep.v9i1.480Palabras clave:
glicosaminoglicanos, colágeno, variación anatómica, tejido conectivoResumen
Los cambios biológicos en el tejido conectivo con el envejecimiento afectan la fisiología del tendón. El objetivo de este estudio fue analizar las propiedades viscoelásticas, la organización estructural y la composición química del tejido conectivo presente en dos tendones (CT y DDFT) de ratas macho de diferentes edades, obtenidos de diferentes sitios anatómicos y sometidos a diferentes demandas funcionales. Los principales hallazgos de este estudio se relacionan con los cambios en las propiedades mecánicas de los tendones (CT y DDFT) con la madurez, y que estos cambios son significativamente más intensos en DDFT que en CT. Las propiedades de hinchamiento de CT y DDFT en ácido acético y agua mostraron cambios significativos con el envejecimiento y difirieron entre tendones. El contenido de hidroxiprolina y glicosaminoglicano de los tendones disminuyó con el envejecimiento en ambos tendones, pero se observaron diferencias significativas entre ellos en los dos solventes. El estudio también muestra que las fibrillas de colágeno en tendones jóvenes son de pequeño diámetro. En individuos mayores, las fibrillas de colágeno son de mayor diámetro. Finalmente, las observaciones sobre el tipo de glicosaminoglicano mostraron que la concentración de proteoglicano de dermatán sulfato fue similar en el tejido conectivo durante el envejecimiento y mayor en la madurez en el tejido conectivo deshilachado. Las propiedades del tejido conectivo experimentan cambios durante el envejecimiento, y estos cambios dependen de las exigencias a las que se ven sometidas las estructuras a medida que envejecen.
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Derechos de autor 2025 Marcelo Augusto Marretto Esquisatto, Andrea Aparecida de Aro, Edson Rosa Pimentel , Laurecir Gomes
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